The use of whole-cell sensors for signal transduction measurements is important in drug discovery efforts. Simply detecting binding of a compound to a receptor does not assure the efficacy of the compound in other aspects of the signal transduction cascade. Whole-cell sensors such as ECIS, however, integrate the entire cellular response to the receptor activation.
This webinar will explain the basic principles of ECIS and data will be presented showing the ability of ECIS to monitor signal transduction events in label-free whole-cell assays. The morphollgical changes responsible for the impedance changes will be further evaluated by modeling the complex impedance data.